I treat retinal eye conditions such as diabetic retinopathy and retinal detachment repair. Further studies to evaluate MIF’s role in the retina are needed. The retina is a vital part of the eye that senses light and sends images to your brain. Ophthalmology, Medical Doctor, Principal in Midwest Retina, Inc. Specific MIF promoter polymorphisms may influence the development of PVR in patients with RD. West Concord, MA 01742 10547 Mackenzie Way, Dublin, OH 43017 View more. Fisher exact test showed a significant decreased frequency of the C7 haplotype in RD-PVR patients compared to RD. Klisovic graduated from the Medicinski Fakultet Sveucilista U Zagrebu in. The rs5844572 7 allele was also lower in RD-PVR patients (5.4%) vs RD (15%) (p=0.0237). 4.9 out of 5 211 Patient Satisfaction Ratings 71 Patient Comments Insurances We Accept 61 About Me My retinal ophthalmology expertise includes managing eye conditions involving the retina and vitreous, a gel-like substance in the eye. Midwest Retina Inc 6655 Post Rd, Dublin, OH, 43016 19 other locations (614) 339-8500 Overview Locations OVERVIEW Dr.
In the RD patients, the C allele of rs755622 was found to be less frequent in RD-PVR than in RD (odds ratio =0.5456 p=0.0310). There was no significant difference between the frequency of the MIF polymorphisms in unaffected regional controls and the RD population. Chi-square and Fisher exact analysis was performed and odds ratios calculated. Johnstone Kim, MD, is a Midwest Retina ophthalmologist treating retinal and vitreous. Two polymorphisms, rs755622 (previously reported as -173G>C) and rs5844572 (previously reported as -794 (CATT) 5-8) were evaluated with allele-specific primer PCR and sequencing frequencies of genotypes, alleles, and the C7 haplotype were compared in patients with data (n=137 RD and 74 RD-PVR). Germline DNA was extracted from mononuclear cells at the OSU Human Cancer Genetic sample bank. Blood samples, vitreous surgical specimens when available, and clinical data were collected. We tested the hypothesis that promoter polymorphisms that influence expression of the pro-inflammatory cytokine macrophage migration inhibitory factor (MIF) are associated with PVR development.Ī multi-center prospective study of 284 American RD patients with PVR (n=114) and without PVR (n= 170) and local unaffected controls (n=202) was conducted under an IRB-approved protocol. Pro-inflammatory factors promote development of proliferative vitreoretinopathy (PVR) in retinal detachment (RD).
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